Funded Research Grants | The Marfan Foundation

Funded Research Grants

2018

  • Mudiaga Sowho, MD, MPH, Johns Hopkins School of Medicine, Hemodynamic Response to Upper Airway Obstruction in Marfan Syndrome, $150,000 2-year Victor A. McKusick Fellowship Grant

  • Yue Xuan, PhD, The Regents of the University of California, San Francisco, Improved Rupture Risk Assessment of Ascending Thoracic Aortic Aneurysms: Influence of Marfan Syndrome on Aneurysm Biomechanics, $100,000 2-year Victor A. McKusick Fellowship Grant

  • Dianna M. Milewicz, MD, PhD, The University of Texas Health Science Center at Houston, Asprosin's Role in the Appetite and Progeroid Appearance of Marfan Lipodystrophy Syndrome and Neonatal Marfan Syndrome Patients, $100,000 2-year Clinical Research Grant

  • Melissa L. Russo, MD, Women & Infants Hospital of Rhode Island, Pregnancy and Other Reproductive Outcomes in Women with Genetic-predisposition for Aortic Dissection, $100,000 2-year Clinical Research Grant

  • Steven Bassnett, PhD, Washington University, Modeling Ocular Aspects of Marfan Syndrome in Mice, $100,000 2-year Faculty Grant 

  • Harry C. Dietz, MD, Johns Hopkins School of Medicine, Identification of Major Genetic Modifiers of Aortic Dissection in Vascular Ehlers Danlos, $100,000 2-year Faculty Grant 

  • J. Geoffrey Pickering, MD, PhD, The University of Western Ontario, Assessment of Aortic Wall Vulnerability in Syndromic Thoracic Aortic Disease by Innovative Magnetic Resonance Imaging, $100,000 2-year Faculty Grant

2017

  • James Foster, PhD, Johns Hopkins School of Medicine, Organ Specific Expression of the Short Isoform of ADAMTS2 and Its Role in Corneal Development, $100,000 2-year Victor A. McKusick Fellowship Grant 

  • Gillian McLellan, BVMS, PhD, DACVO, University of Wisconsin-Madison, Delineating Pathology of the aqueous humor outflow pathways in animals with LTBP2 mutation, $75,000 2-year Early Investigator Grant 

  • Francesca Seta, PhD, Boston University School of Medicine, Preclinical Study to test the Efficacy of Sirtuin-1 against the Vascular Complications of Marfan's and Related Disorders, $75,000 2-year Early Investigator Grant 

  • Joseph Turek, MD, University of Iowa,A TRPC4-dependent amplification pathway contributes to aortic aneurysm progression in Marfan syndrome, $75,000 2-year Early Investigator Grant  

  • James Hoekel, OD, Washington University, Intraocular Lens Implant and Corneal Laser Surgery in Visually Impaired Children with Marfan Syndrome, $100,000 2-year Clinical Research Grant  

  • Bettina Willie, PhD,  McGill University, Osteocyte Mechanobiology in Marfan Syndrome, $100,000 2-year Faculty Grant  

  • Jonathan Weinsaft, M.D., Weill-Cornell Medical College, Cardiovascular MRI Wall Stress Characterization for Prediction of Adverse Aortic Remodeling Following Surgical Aneurysm Repair, $100,000 2-year Faculty grant 

  • Pascal Bernatchez, Ph.D., University of British Columbia, Endothelial Function in Marfan: A Target and Clinical Marker, $100,000 2-year Faculty Grant  


  • Juan Miguel Redondo-Moya, Ph.D., Spanish National Cardiovascular Centre, NO Signaling and ADAMTS1 Substrates in the Pathogenesis of Marfan Syndrome, $100,000 2-year Faculty Grant

2016

  • Maryline Abrial, PhD, Massachusetts General Hospital, Investigating a Novel Genetic Model of Aortic Root Aneurysm in Zebrafish, $100,000 2-year McKusick Fellowship Grant

  • Vallabhajosyula Prashanth MD, MS, University of Pennsylvania, Plasma Endothelial Specific Exosome Profiling in Marfan Syndrome, $75,000 2-year Early Investigator Grant

  • Rouf Rosanne MD, Johns Hopkins School of Medicine, Using an Established MFS Mouse Model to Understand MVP Pathogenesis, $75,000 2- year Early Investigator Grant

  • Dr. Suneel Apte, MBBS, DPhil, Cleveland Clinic, Fibrillin Microfibril Regulation by ADAMTSL3, $100,000 2-year Faculty Grant

  • Seda Tierney, MD, Stanford University and Mitra Esfandiarei, Ph.D. Midwestern University, Children and Adolescents with Marfan Syndrome: 10,000 Healthy Steps and Beyond, $100,000 2-year Faculty Grant

  • Zhiyong Lin, PhD, Case Western Reserve University, Allosteric Activation of PP2A to Limit the Progression of Aortic Aneurysm in Marfan Syndrome, $100,000 2-year Faculty Grant 

  • Jessica Wagenseil, DSc, Washington University, Arterial Tortuosity and Aneurysms, $100,000 2-year Faculty Grant

2015

  • Emanuela Branchetti, PhD, University of Pennsylvania, RAGE/sRAGE Axis: Novel Biomarker and Mechanism of Ascending Aortic Aneurysm Development in Marfan Syndrome. $75,000 2-year Early Investigator Grant

  • Mitra Esfandiarei, PhD, Midwestern University, Role of Caveolin-1 in the Progression of Aortic Aneurysm in Marfan Syndrome. $75,000 2-year Early Investigator Grant

  • Parmanand Singh, MD, Weill Cornell Medical College, Predictive Value of Inflammation and Arterial Stiffness in Thoracic Aortic Aneurysm. $75,000 2-year Early Investigator Grant

  • Lakshmi Venkatraman PhD, Beth Israel Deaconess Medical Center, Systems Biology of Tgfb in Vascular Complications of Marfan Syndrome. $100,000 2-year McKusick Fellowship Grant

  • Gustavo Egea, PhD, Institut d’Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Apolinker P144: A Potential anti-TGF-b Therapeutic Tool to Fight Against Aortic Aneurysms in Marfan Syndrome. $80,000 2-year Faculty Grant

  • Christina Gurnett, MD, PhD, Washington University School of Medicine, Zebrafish Models of Human Fibrillinopathies. $100,000 2-year Faculty Grant

  • Francesco Ramirez, PhD, Icahn School of Medicine at Mount Sinai, Endothelial Dysfunction as the Trigger of Aortic Aneurysm in the Marfan Syndrome. $100,000 2-year Faculty Grant

  • Daniel Rifkin, PhD, New York University School of Medicine, Genetic Interrogation of the Role of LTBPs in Aortic Aneurysms. $100,000 2-year Faculty Grant

2014

  • Dirk Hubmacher, PhD, Cleveland Clinic Foundation, Promotion of Microfibril Assembly in Aortic Smooth Muscle Cells in a Mouse Model for Marfan Syndrome. $75,000 2-year Early Investigator Grant

  • Douglas Mah, MD, Boston Children’s Hospital, Ventricular Ectopy and other Rhythm Abnormalities in Children and Young Adults. $37,375  1-year Early Investigator Grant

  • Francesca Seta, PhD, Boston University School of Medicine, Sirtuin1 in Aortic Remodeling and Dissection. $75,000 2-year Early Investigator Grant

  • David Alvarado, PhD, Washington University, Expanding the Spectrum of Fibrillin Mutations in Marfan Syndrome and Related Disorders. $100,000 2-year McKusick Fellowship Grant

  • Elona Gavazi, MD, Columbia University Medical Center, Characterizing the Ophthalmalmic Phenotype of Marfan Syndrome Mouse Model and Demonstrating Pre-Clinical Efficacy of Preventative Therapeutic Interventions in this Heterozygous Model. $150,000 2-year McKusick Fellowship Grant

  • Steven Bassnett, PhD, Washington University School of Medicine, Role of Microfibrils in the Biology and Pathology of the Eye. $100,000 2-year Faculty Grant

  • Silvia Smaldone, PhD, Icahn School of Medicine at Mount Sinai, Characterization of Long Bone Overgrowth in Marfan Syndrome. $100,000 2-year Faculty Grant

  • Dudley Strickland, PhD, Role of LRP1 in Regulating Development of Marfan Syndrome. $100,000 2-year Faculty Grant

2013

  • Michael Fischbein, MD, Stanford University, Role of MicroRNA-29b during Aneurysm Formation in Aortic Segments of Different Embryologic Origin. $75,000 2-year Early Investigator Grant

  • Hadas Shiran, MD, Stanford University School of Medicine, Risk Factors for Complications of Thoracic Aortic Aneurysms. $75,000 2-year Early Investigator Grant

  • Venkateswaran Subramanian, PhD, University of Kentucky Research Foundation, Role of Calpain in AngII-induced Ascending Aortic Aneurysm. $75,000 2-year Early Investigator Grant

  • Josephine Galatioto, PhD, Mount Sinai School of Medicine, Characterization of Putative Triggers of Early Thoracic Aortic Aneurysm in Marfan Syndrome. $100,000 2-year McKusick Fellowship Grant

  • Sarah J. Parker, PhD, Cedars-Sinai Medical Center, Determination of the Molecular Mechanisms that Underlie the Anatomical Specificity of Aortic Aneurysm in Marfan Syndrome. $100,000 2-year McKusick Fellowship Grant

  • Rachel Kuchtey, MD, PhD, Vanderbilt University, Glaucoma in a Mouse Model of Marfan Syndrome. $100,000 2-year Faculty Grant

  • Lynn Y. Sakai, PhD, Shriners Hospital for Children, Targeting Collaborative Signaling Pathways in Marfan Syndrome. $100,000 2-year Faculty Grant

  • Chen Yan, PhD, University of Rochester, Vascular Smooth Muscle Cell Phenotype Transition and Thoracic Aortic Aneurysm in Marfan Syndrome. $100,000 2-year Faculty Grant