RESEARCH GRANTS FUNDED THROUGH THE NMF RESEARCH PROGRAM
2012
Rajan Jain, MD, University of Pennsylvania, PA, Tissue – Tissue Interactions in Marfan Syndrome and Related Disorders - $150,000 Two-Year McKusick Fellowship Grant
John A. Eleteriades, MD, Yale University, CT, Peripheral Blood RNA Expressionas a Biomarker of Thoracic Aortic Aneurysm in Non-Syndromic Versus Marfan Patients - $50,000 One-Year Faculty Grant
Jay D. Humphrey, MD, Yale University, CT, Dysfunctional Aortic Wall Homeostatis & Loss of Structural Integrity in Marfan Syndrome - $50,000 One-Year Faculty Grant
George Tellidies, MD, Yale University, CT, TGF- β Sigaling in Vascular Smooth Muscle Cells - $100,000 Two-Year Faculty Grant
2011
Jefferson Doyle, MD, Johns Hopkins Hospital, MD, Investigating the Deleterious Effects of Calcium Channel Blockers in Marfan Syndrome - $150,000 Two-Year McKusick Fellowship Grant
Xiaofeng Chen, MD, Ph.D., University of Kentucky, KY, Role of TGF-b1 in AngII-induced Ascending Aortic Aneurysm - $150,000 Two-Year McKusick Fellowship Grant
Jennifer Habashi, MD, Johns Hopkins Hospital, MD, Using an Established Marfan Mouse Model to Understand the Increased Risk and Molecular Underpinnings of Aortic Dissection during Pregnancy with the Goal to Discover New Treatment Strategies - $100,000 Faculty Grant
Gustavo Egea, Ph.D., University of Barcelona School of Medicine, Spain, Membrane Trafficking of TGFβ Teceptors in Marfan Cell Lines: A New Strategy to Handle the TGFβ-Induced Signaling - $50,000 Faculty Grant
Michael P. Fischbein, MD, Ph.D., Stanford University, CA, NFkb Dependent mlR-29b Over-Expression Participates in Early Aneurysm Development in Marfan Syndrome -$100,000 Faculty Grant
Marion Hofman-Bowman, MD, University of Chicago, IL, Role of S100A12 in Thoracic Aortic aneurysms and Dissection - $50,000 Faculty Grant
Francesco Ramirez, Ph.D., Mount Sinai School of Medicine, NY, Genetic Dissection of Cardiac Disease in Marfan Syndrome - $50,000 Faculty Grant
Wanfen Xiong, MD, Ph.D., University of Nebraska Medical Center, NE, Doxycycline Prevents Aneurysm Formation in Marfan Syndrome Through the Inhibition of Matrix Metalloproteinase-2 Which Activates Transforming - $100,000 Two-Year Faculty Grant
2010
Dr. Mark Lindsay, MD, Johns Hopkins Hospital, MD, Second Heart Field Development Underlies Proximal Aortic Aneurysm in Marfan Syndrome - $100,000 two-year Fellow-to-Faculty Grant
Dr. Alison Frand, Ph.D., UCLA, CA, Regulation of the Firbillin-1 like protein of C. elegans - $100,000 two-year Faculty Grant
Dr. Daniel Rifkin, Ph.D, NYU, Matrix Hierarchies in Marfan syndrome and Related Disorders - $50,000 one-year Faculty Grant Award
Ronald V. Lacro, MD, Children’s Hospital Boston, MA, Marfan Quality of Life Ancillary Study, An Ancillary Study to the PHN Marfan Trial of Beta Blocker Therapy (Atenolol) vs. Angiotensin II Receptor (Losartan) in Individuals with Marfan Syndrome - $100,000 Four-Year Clinical Trial Ancillary Grant
Hal Dietz, MD, Johns Hopkins Hospital, MD, Circulating TGFβ Levels in Marfan Syndrome - $40,000 Four-Year Clinical Trial Ancillary Grant
2009
Jefferson Doyle, MBBCHIR, MHS, MA, Johns Hopkins Hospital. The Benefits of Antagonizing ERK Signaling to Modify the Pathogenesis of Marfan Syndrome. 2-year McKusick Fellowship grant award - $150,000
Christine Papke, Ph.D., The University of Texas Medical School at Houston. Molecular Pathogenesis in Mouse Models of Thoracic Aortic Aneurysm and Dissections. 2-year McKusick Fellowship grant award - $100,000
Suneel Apte, Ph.D. Cleveland Clinic. ADAMTSL4, Fibrillin-1 and Ectopia Lentis. 1-year grant award - $50,000
Joseph Coselli, MD, Baylor College of Medicine. Aortic Valve Sparing Operative Outcomes in Patients with Marfan Syndrome. 2-year grant award - $100,000
2008
Ami Bhatt, M.D., Brigham and Women’s Hospital, Boston, MA. 2-year grant award, $150,000
Improving Aortic Health in Adults with Marfan Syndrome: Losartan vs Atenolol
Julie Hoover-Fong, M.D., Johns Hopkins University, Baltimore, MD. Ancillary study to the Atenolol vs. Losartan Clinical Trial 6-year grant, $922,340
Musculoskeletal Phenotype of Marfan Patients.
Robert Mecham, Ph.D., Professor, Washington University, St. Louis, MO, 2-year grant award - $100,000, MAGP: Modifier of Microfibril Function
Hiromi Yanagisawa, M.D., Ph.D. Assistant Professor, UT Southwestern Medical Center.1-year grant award, $50,000
Investigation of the potential role of fibulin-4 in the pathogenesis of Marfan Syndrome,
Jennifer Pardo Habashi, M.D., Assistant Professor, Johns Hopkins University, Baltimore, MD, 1-year grant award $50,000.
Exploration of synergistic therapeutic strategies with Losartan to improve all cause survival in an exaggerated mouse model of Marfan Syndrome.
2007
Joseph Coselli, M.D., Baylor College of Medicine, Houston, TX. 2-year Target Grant Award, $276,368.
Aortic Valve Operative Outcomes for Marfan Patients Target Grant
Raymond Eid, M.D., Yale University, CT, Victor A. McKusick Fellowship 1-year award $75,000
Role of IL-17A in Marfan Syndrome
Daniel B. Rifkin, Ph.D., Professor, New York University Medical Center, NY. 1-year grant award. $50,000
Mechanism of Latent TGF-ƒÒ Activation in Marfan Cells
Luca Carta, Ph.D. Instructor, Pediatrics UMDNJ-Robert Wood Johnson Medical School, NJ. 1-year grant award $50,000
Pathophysiology of skeletal deformities in the Marfan syndrome.
Peter Robinson, M.D., MSc. Research Scientist, Institut of Medical Genetics, Charite Universitatsmedizin. 1-year grant award, $50,000
Characterization of the mechanisms of fibrillin gene regulation.
Dr. Dan Roden, Vanderbilt University Medical Center, TN and Dr. Bart Loeys, Ghent University, Belgium. Ancillary study to the Atenolol vs. Losartan clinical trial Four-year grant $781,722
Study of the role of genetic variation in the phenotype variability and response treatment in patients with Marfan syndrome.
2006
Michael Reiss, MD, Professor of Medicine, Molecular Genetics, Microbiology and Immunology. The Cancer Institute of New Jersey, New Brunswick, NJ. 2-year grant award $100,000.
Structure-function studies of transforming growth factor-b receptor mutations in Marfan-like syndromes.
Hal C. Dietz, MD with Nishant D. Patel, Johns Hopkins University, Baltimore, MD. 1-year grant award, $50,000
A refined interrogation of mechanism and therapy in mouse models of Marfan syndrome.
Jennifer Pardo Habashi, MD, Johns Hopkins Hospital, Baltimore, MD, Victor A. McKusick Fellowship 2-year grant award $150,000
The Beneficial Effects of Antagonizing TGF-ƒÒ and Related Mediators in Modifying the Pathogenesis of Marfan Syndrome
2005
Lynn Y. Sakai, Ph.D., Oregon Health and Science University and Shriners Hospital for Children, Portland, OR. 2-year grant award, $100,000
Testing the Fibulins as Biomarkers for Aortic Disease in the Marfan Syndrome
Suneel S. Apte, MBBS, D.Phil, Cleveland Clinic Foundation, Cleveland, OH. $50,000 1-year grant award
ADAMTS10 and Weill-Marchesani Syndrome.
Friedrich Laub, Ph.D. Instructor, Hospital for Special Surgery, New York, NY. 1-year grant award, $25,000
Genetic Analysis of Low Bone Mass in Marfan Syndrome
Heidi Connolly, MD, Mayo Clinic – Aortic Valve Operative Outcomes in Marfan Patients Imaging Core – $350,000 6-year grant Target Grant
2004
Elaine C. Davis, Ph.D. McGill University, Montreal, CA. 2-year grant award, $100,000
Fibrillin-1 and Fibulin-5 Interactions: Possible Role in Pathogenesis of Marfan Syndrome.
J. Michael Shipley, Ph.D. Washington University School of Medicine, St. Louis, MO. 1-year grant award, $50,000
Conditional Targeting of the LTBP-2 Gene in Smooth Muscle
Lynn Y. Sakai, Ph.D., Oregon Health and Science University and Shriner’s Hospital for Children, Portland, OR. 2-year grant award, $100,000.
Testing the Fibulins as Biomarkers for Aortic Disease in the Marfan Syndrome
Suneel S. Apte, MBBS, D.Phil, Cleveland Clinic Foundation, Cleveland, OH. 1-year grant award, $50,000 award.
ADAMTS10 and Weill-Marchesani Syndrome.
Friedrich Laub, Ph.D. Instructor, Hospital for Special Surgery, New York, NY. 1-year grant award, $25,000 award.
Genetic Analysis of Low Bone Mass in Marfan Syndrome
2003
Alan Cheng, MD, Johns Hopkins University School of Medicine, Baltimore, MD. 2-year grant award, $100,000
Developing Genetic Ameliorate the Cardiovascular Phenotype of Marfan Syndrome.
Irene H. Maumenee, MD, Johns Hopkins Center for Hereditary Eye Diseases. 1-year grant award, $50,000
Design and Clinical Trial of a Posterior Chamber Intraocular Lens for Patients with the Marfan Syndrome.
2002
Robert J. Herfkens, MD, Stanford University, Stanford, CA. 2-year grant award, $99,145
Assessment of Mechanical Properties of the Aortic Arch in Patients with Marfan Syndrome by Means of Magnetic Resonance Imaging (MRI).
Lynn Y. Sakai, Ph.D., Shriners Hospital for Children, Portland, OR. 1-year grant award $50,000. Quantitative Analyses of Fibrillin-1.
2001
Daniel P. Judge, The Johns Hopkins School of Medicine, Baltimore, MD. 2-year grant award, $100,000
Pathogenesis and Therapy of Marfan Vascular Disease
Reed E. Pyeritz, M.D., Ph.D., University of Pennsylvania School of Medicine, Philadelphia, PA. 1-year grant award, $50,000
Factors that Predispose to Aortic Dissection in the Marfan Syndrome
Maurice Godfrey, Ph.D., Nebraska Medical Center, Omaha, NE, 1-year grant award, $50,000
Doxycycline versus Propranolol: Effects on Aneurysms in a Marfan Mouse
Cheryl L. Maslen, Ph.D., Oregon Health Sciences University, Portland, OR. 1-year grant award, $50,000
Genetic Variation of Fibrillin-2 as a Risk Factor in Congenital Heart Disease
2000
Craig T. Basson, M.D., Ph.D., Weill Medical College of Cornell University, New York, NY. 1-year grant award, $50,000
Identification of a Gene Defect for Familial Aortic Aneurysms
Robert P. Mecham, Ph.D., Washington University School of Medicine, St. Louis, MO. 1-year grant award, $50,000
Microfibril Structure and Marfan Syndrome
Dianna Milewicz, M.D., Ph.D., University of Texas Health Science Center, Houston, TX, 1-year grant award, $50,000
Genetic Basis of Aortic Aneurysms/Dissections
1999
Francesco Ramirez, Ph.D., Mount Sinai School of Medicine, New York, NY. 1-year grant award, $10,000
Creation of a Mouse Model for Marfan Syndrome
Daniel B. Rifkin, Ph.D., New York University School of Medicine, New York, NY. 1-year grant award, $10,000
Normal and Pathological Functions of the Latent TGF-ƒÒ Binding Proteins
Scott A. LeMaire, M.D., Baylor College of Medicine, Houston, TX. 1-year grant award, $10,000
Aortic Gene Therapy: In Vivo Gene Transfer Into the Aortic Root During Cardiopulmonary Bypass
Anji T. Yetman, M.D., Arkansas Children’s Hospital, Little Rock, AR, 1-year grant award, $10,000
The Effect of ACE Inhibitors on Aortic Elastic Properties, Aortic Growth and Left Ventricular Size and Function in Marfan Patients
Leena Ala-Kokko, M.D., Ph.D., MCP-Hahnemann University, Philadelphia, PA. 1-year grant award, $10,000
Mutation screening procedure for the Fibrillin-1 and Fibrillin-2 genes in patients with Marfan syndrome and contractural arachnodactyly
1998
Francesco Ramirez, Ph.D., Mount Sinai School of Medicine, New York, NY. 1-year grant award, $10,000
Creation of a Mouse Model for Marfan Syndrome
Elizabeth A. Putnam, Ph.D., University of Texas Medical School, Houston, TX. 1-year grant award, $10,000
Molecular Basis of the Similarities Between Neonatal Marfan Syndrome and Congenital Contractural Arachnodactyly
Walter J. Rogers, Jr., M.S. and Reed E. Pyeritz, M.D., Ph.D., Allegheny University of the Health Sciences, Pittsburgh, PA. 1-year grant award, $10,000
Effect of Pharmacological Therapy on Regional Mechanical Properties in the Marfan Aorta
Heinz Furthmayr, M.D., Stanford University Medical Center, Stanford, CA, 1-year grant award, $10,000
Clinical Consequences of Fibrillin-1 Mutations: Predictions and Prognostic Considerations Based on In Vitro Assays
Daniel B. Rifkin, Ph.D., New York University School of Medicine, New York, NY. 1-year grant award, $10,000
Biological Functions of the Latent Transforming Growth Factors
Elaine C. Davis, Ph.D., University of Texas Southwestern Medical Center, Dallas, Texas. 1-year grant award $10,000.
Characterization of an In Vitro Model for the Study of Microfibril Ultrastructure and Elastic Fiber Assembly
Cheryl Maslen, Ph.D., Oregon Health Sciences University, Portland, OR. 1-year grant award $10,000
Further Characterization of a Candidate Gene for the Second Marfan Syndrome Locus
Ruth J. Okamoto, D.Sc., Washington University, St. Louis, MO. 1-year grant award, $10,000
Biaxial Mechanical Properties of Aortic Tissue from Patients with the Marfan Syndrome
1997
Cheryl Maslen, Ph.D., Oregon Health Sciences University, Portland, OR. 1-year grant award, $10,000
Characterization of a Candidate Gene for the Second Marfan Syndrome Locus
Francesco Ramirez, Ph.D., Mt. Sinai School of Medicine, New York, NY. 1-year grant award, $10,000
Creation of a Mouse Model for Marfan Syndrome
Maurice Godfrey, Ph.D., University of Nebraska Medical Center, Omaha, NE. 1-year grant award, $10,000
Molecular Basis of Marfan-like Syndromes
Paul D. Sponseller, M.D., Johns Hopkins Hospital, Baltimore, MD. 1-year grant award, $10,000
Dural Ectasia in the Marfan Spine
Charlotte L. Phillips, Ph.D., University of Missouri, Columbia, MO. 1-year grant award, $10,000
Type I Collagen Abnormalities in Patients with Marfan-like Connective Tissue Disorders and Normal Fibrillin
1996
Heinz Furthmayr, M.D., Stanford University, CA. 1-year grant award, $10,000
Autosomal Dominant Ascending Aortic Aneurysm Without Features of Marfan Syndrome
Hal C. Dietz, M.D., Johns Hopkins University School of Medicine, Baltimore, MD. 1-year grant award, $10,000
U1snRNA as a Vehicle for the Delivery of Antisense Targeting Sequences
Francesco Ramirez, Ph.D., Mount Sinai School of Medicine, NY. 1-year grant award, $10,000
Creation of a Mouse Model for Marfan Syndrome
1995
Leena Peltonen, M.D., Ph.D., National Public Health Institute, Helsinki, Finland. 1-year grant award, $10,000
In Vitro Expression of Mutagenized Fibrillin Constructs
Heinz Furthmayr, M.D., Stanford University School of Medicine, CA. 1-year grant award, $10,000
A Study of Fibrillin Biosynthesis on Patients with Marfan Syndrome and Related Disorders
Francesco Ramirez Ph.D., Mount Sinai School of Medicine, NY. 1-year grant award, $5,000
Characterization of a Mouse Model of Marfan Syndrome
1994
Elaine C. Davis, Ph.D., and Robert P. Mecham, Ph.D., Washington University School of Medicine, St. Louis, MO, 1-year grant award, $10,000
Fibrillin Organization in Microfibrils: Role of Fibrillins in Elastic Fiber Assembly
Dianna M. Milewicz, M.D., Ph.D., University of Texas Medical School, Houston, TX, 1-year grant award, $10,000
Methodology to Quantify Message Levels for FBN1 & FBN2 Genes
Philip F. Giampietro, M.D., Ph.D., New York Hospital/Cornell Medical Center, New York, NY. 1-year grant award, $5,000
Correlating Genotype and Phenotype
1993
Heinz Furthmayr, M.D., Stanford University Medical Center, Stanford, CA. 1-year grant award, $10,000
Fibrillin Biosynthesis in Dermal Fibroblasts
Hal C. Dietz, M.D., Johns Hopkins Hospital, Baltimore, MD. 1-year grant award, $10,000
Toward a Porcine Model of the Marfan Syndrome: Creation and Characterization of a Porcine FBN1 Expression Vector
Dianna Milewicz, M.D., Ph.D., University of Texas Medical Center, Houston, TX. 1-year grant award, $5,000
Fibrillin Synthesis and Processing as Diagnostic Tests for Marfan Syndrome
Maurice Godfrey, Ph.D., University of Nebraska Medical Center, Omaha, NE. 1-year grant award, $5,000
Structural Analyses of Fibrillin Mutations in the Marfan Syndrome
Sharada Truter, Ph.D., Mt. Sinai Medical Center, New York, NY. 1-year grant award, $5,000
Regulation of Fibrillin Expression
1992
Heidi Stuhlman, Ph.D., Mt. Sinai Medical Center, New York, NY. 1-year grant award $10,000
Toward a Mouse Model for Marfan Syndrome
Cheryl L. Maslen, Ph.D., Oregon Health Sciences University, Portland, OR. 1-year grant award, $10,000
The Effect of Marfan Mutations on Fibrillin Domains
Elaine Davis, Ph.D., Robert P. Mecham, Ph.D., Jewish Hospital/Washington University School of Medicine, St. Louis, MO. 1-year grant award, $5,000
Marfan Tissue Microfibrils: Ultrastructural and Compositional Features
Petros Tsipouras, M.D., University of Connecticut Health Center, Farmington, CT. 1-year $5,000
The Development of an Antisense Based Therapy for Marfan Syndrome
1991
Clair Francomano, M.D., Johns Hopkins Hospital, Baltimore, MD. 1-year grant award, $10,000
Molecular Genetics of the Marfan Syndrome
Leena Peltonen, M.D., Ph.D., National Public Health Institute, Helsinki, Finland. 1-year grant award $10,000
Molecular Genetics of the Marfan Syndrome
Maurice Godfrey, Ph.D., University of Nebraska Medical Center, Omaha, NE. 1-year grant award, $5,000
Molecular, Immunochemical, and Biochemical Correlation of Fibrillin Mutations in the Marfan Syndrome
Cheryl Maslen, Ph.D., Oregon Health Sciences University, Portland, OR. 1-year grant award, $5,000
The Role of the Fibrillin Gene in the Marfan Syndrome
1990
Petros Tsipouras, M.D., University of Connecticut Health Center, Farmington, CT. 1-year grant award, $5,000
Saturation Mapping of the Area Surrounding the Marfan Syndrome Locus
Dianna J. McGookey, M.D., Ph.D., and Peter Byers, M.D., University of Washington School of Medicine, Seattle, WA, 1-year grant award. $5,000.
Molecular Defects in the Marfan Syndrome
1989
Dianna J. McGookey, M.D., Ph.D. and Peter Byers, M.D., University of Washington, Seattle, WA. 1-year grant award, $3,000
Abnormalities in Fibrillin Observed in Cells from People with the Marfan Syndrome
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