Funded Research Grants | The Marfan Foundation

Funded Research Grants

2017

  • James Foster, PhD, Johns Hopkins School of Medicine, Organ Specific Expression of the Short Isoform of ADAMTS2 and Its Role in Corneal Development, $100,000 2-year Victor A. McKusick Fellowship Grant 

  • Gillian McLellan, BVMS, PhD, DACVO, University of Wisconsin-Madison, Delineating Pathology of the aqueous humor outflow pathways in animals with LTBP2 mutation, $75,000 2-year Early Investigator Grant 

  • Francesca Seta, PhD, Boston University School of Medicine, Preclinical Study to test the Efficacy of Sirtuin-1 against the Vascular Complications of Marfan's and Related Disorders, $75,000 2-year Early Investigator Grant 

  • Joseph Turek, MD, University of Iowa,A TRPC4-dependent amplification pathway contributes to aortic aneurysm progression in Marfan syndrome, $75,000 2-year Early Investigator Grant  

  • James Hoekel, OD, Washington University, Intraocular Lens Implant and Corneal Laser Surgery in Visually Impaired Children with Marfan Syndrome, $100,000 2-year Clinical Research Grant  

  • Bettina Willie, PhD,  McGill University, Osteocyte Mechanobiology in Marfan Syndrome, $100,000 2-year Faculty Grant  

  • Jonathan Weinsaft, M.D., Weill-Cornell Medical College, Cardiovascular MRI Wall Stress Characterization for Prediction of Adverse Aortic Remodeling Following Surgical Aneurysm Repair, $100,000 2-year Faculty grant 

  • Pascal Bernatchez, Ph.D., University of British Columbia, Endothelial Function in Marfan: A Target and Clinical Marker, $100,000 2-year Faculty Grant  


  • Juan Miguel Redondo-Moya, Ph.D., Spanish National Cardiovascular Centre, NO Signaling and ADAMTS1 Substrates in the Pathogenesis of Marfan Syndrome, $100,000 2-year Faculty Grant

2016

  • Maryline Abrial, PhD, Massachusetts General Hospital, Investigating a Novel Genetic Model of Aortic Root Aneurysm in Zebrafish, $100,000 2-year McKusick Fellowship Grant

  • Vallabhajosyula Prashanth MD, MS, University of Pennsylvania, Plasma Endothelial Specific Exosome Profiling in Marfan Syndrome, $75,000 2-year Early Investigator Grant

  • Rouf Rosanne MD, Johns Hopkins School of Medicine, Using an Established MFS Mouse Model to Understand MVP Pathogenesis, $75,000 2- year Early Investigator Grant

  • Dr. Suneel Apte, MBBS, DPhil, Cleveland Clinic, Fibrillin Microfibril Regulation by ADAMTSL3, $100,000 2-year Faculty Grant

  • Seda Tierney, MD, Stanford University and Mitra Esfandiarei, Ph.D. Midwestern University, Children and Adolescents with Marfan Syndrome: 10,000 Healthy Steps and Beyond, $100,000 2-year Faculty Grant

  • Zhiyong Lin, PhD, Case Western Reserve University, Allosteric Activation of PP2A to Limit the Progression of Aortic Aneurysm in Marfan Syndrome, $100,000 2-year Faculty Grant 

  • Jessica Wagenseil, DSc, Washington University, Arterial Tortuosity and Aneurysms, $100,000 2-year Faculty Grant

2015

  • Emanuela Branchetti, PhD, University of Pennsylvania, RAGE/sRAGE Axis: Novel Biomarker and Mechanism of Ascending Aortic Aneurysm Development in Marfan Syndrome. $75,000 2-year Early Investigator Grant

  • Mitra Esfandiarei, PhD, Midwestern University, Role of Caveolin-1 in the Progression of Aortic Aneurysm in Marfan Syndrome. $75,000 2-year Early Investigator Grant

  • Parmanand Singh, MD, Weill Cornell Medical College, Predictive Value of Inflammation and Arterial Stiffness in Thoracic Aortic Aneurysm. $75,000 2-year Early Investigator Grant

  • Lakshmi Venkatraman PhD, Beth Israel Deaconess Medical Center, Systems Biology of Tgfb in Vascular Complications of Marfan Syndrome. $100,000 2-year McKusick Fellowship Grant

  • Gustavo Egea, PhD, Institut d’Investigacions Biomediques August Pi I Sunyer (IDIBAPS), Apolinker P144: A Potential anti-TGF-b Therapeutic Tool to Fight Against Aortic Aneurysms in Marfan Syndrome. $80,000 2-year Faculty Grant

  • Christina Gurnett, MD, PhD, Washington University School of Medicine, Zebrafish Models of Human Fibrillinopathies. $100,000 2-year Faculty Grant

  • Francesco Ramirez, PhD, Icahn School of Medicine at Mount Sinai, Endothelial Dysfunction as the Trigger of Aortic Aneurysm in the Marfan Syndrome. $100,000 2-year Faculty Grant

  • Daniel Rifkin, PhD, New York University School of Medicine, Genetic Interrogation of the Role of LTBPs in Aortic Aneurysms. $100,000 2-year Faculty Grant

2014

  • Dirk Hubmacher, PhD, Cleveland Clinic Foundation, Promotion of Microfibril Assembly in Aortic Smooth Muscle Cells in a Mouse Model for Marfan Syndrome. $75,000 2-year Early Investigator Grant

  • Douglas Mah, MD, Boston Children’s Hospital, Ventricular Ectopy and other Rhythm Abnormalities in Children and Young Adults. $37,375  1-year Early Investigator Grant

  • Francesca Seta, PhD, Boston University School of Medicine, Sirtuin1 in Aortic Remodeling and Dissection. $75,000 2-year Early Investigator Grant

  • David Alvarado, PhD, Washington University, Expanding the Spectrum of Fibrillin Mutations in Marfan Syndrome and Related Disorders. $100,000 2-year McKusick Fellowship Grant

  • Elona Gavazi, MD, Columbia University Medical Center, Characterizing the Ophthalmalmic Phenotype of Marfan Syndrome Mouse Model and Demonstrating Pre-Clinical Efficacy of Preventative Therapeutic Interventions in this Heterozygous Model. $150,000 2-year McKusick Fellowship Grant

  • Steven Bassnett, PhD, Washington University School of Medicine, Role of Microfibrils in the Biology and Pathology of the Eye. $100,000 2-year Faculty Grant

  • Silvia Smaldone, PhD, Icahn School of Medicine at Mount Sinai, Characterization of Long Bone Overgrowth in Marfan Syndrome. $100,000 2-year Faculty Grant

  • Dudley Strickland, PhD, Role of LRP1 in Regulating Development of Marfan Syndrome. $100,000 2-year Faculty Grant

2013

  • Michael Fischbein, MD, Stanford University, Role of MicroRNA-29b during Aneurysm Formation in Aortic Segments of Different Embryologic Origin. $75,000 2-year Early Investigator Grant

  • Hadas Shiran, MD, Stanford University School of Medicine, Risk Factors for Complications of Thoracic Aortic Aneurysms. $75,000 2-year Early Investigator Grant

  • Venkateswaran Subramanian, PhD, University of Kentucky Research Foundation, Role of Calpain in AngII-induced Ascending Aortic Aneurysm. $75,000 2-year Early Investigator Grant

  • Josephine Galatioto, PhD, Mount Sinai School of Medicine, Characterization of Putative Triggers of Early Thoracic Aortic Aneurysm in Marfan Syndrome. $100,000 2-year McKusick Fellowship Grant

  • Sarah J. Parker, PhD, Cedars-Sinai Medical Center, Determination of the Molecular Mechanisms that Underlie the Anatomical Specificity of Aortic Aneurysm in Marfan Syndrome. $100,000 2-year McKusick Fellowship Grant

  • Rachel Kuchtey, MD, PhD, Vanderbilt University, Glaucoma in a Mouse Model of Marfan Syndrome. $100,000 2-year Faculty Grant

  • Lynn Y. Sakai, PhD, Shriners Hospital for Children, Targeting Collaborative Signaling Pathways in Marfan Syndrome. $100,000 2-year Faculty Grant

  • Chen Yan, PhD, University of Rochester, Vascular Smooth Muscle Cell Phenotype Transition and Thoracic Aortic Aneurysm in Marfan Syndrome. $100,000 2-year Faculty Grant